ABSTRACT
This study presents an experimental framework to validate τ-tipping thresholds in viral assays, using delay differential equations and TCID 50 assays with antiviral interventions. The methodology enables the determination of critical thresholds for viral population extinction due to replication time lags.
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Key findings
Identified τ-tipping as a distinct mechanism for viral population extinction.
Established a dose-response relationship between replication lag and population viability.
Proposed a multi-well experimental design with time-series monitoring for early warning signal detection.
Limitations & open questions
Further research needed to apply findings to a broader range of viral populations.
The study's framework needs validation across different viral types and environments.