This research proposes Temporal Shearing Super-Resolution Microscopy (TSSRM), integrating optical time-stretch encoding with structured illumination for label-free nanoscale imaging. TSSRM encodes high-resolution spatial information into the temporal domain, enabling single-shot super-resolution image acquisition at megahertz frame rates.
Key findings
TSSRM achieves label-free nanoscopy with unprecedented spatiotemporal resolution.
The technology enables single-shot super-resolution image acquisition at megahertz frame rates.
Expected performance includes lateral resolution below 100 nm and frame rates exceeding 1 MHz.
The approach maintains compatibility with label-free imaging modes.
Limitations & open questions
The research is a proposal and requires experimental validation.
Potential limitations in practical implementation and scalability are not yet known.